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施扬博士1991-1993年任哈佛大学医学院细胞和分子生理学助理教授。1993-1996年任哈佛大学医学院病理系助理教授，并且在1996年晋升为该系的副教授。2004年开始，晋升为哈佛大学医学院病理系终身正教授。施扬教授主要研究方向为染色质和基因转录。当前的研究重点包括基于DNA为载体的RNA技术的研究，以及通过对第一组蛋白去甲基化酶的研究驳斥了组蛋白的甲基化不会在酶的作用下被逆转的原则。
实验室联系人：郭睿
联系电话：54237874
Email：guorui@fudan.edu.cn
代表论文——————————————————————————————
1. Whetstine, JR., Nottke, A., Lan, F., Huarte, M., Smolikov, S., Chen, Z., Spooner, E., Li, E., Zhang, G.,Colaiacovo, M., and Shi, Y. (2006). Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases. Cell Vol 125:467-81.
2. Chen, Z., Zhang, J., Whetstine, JR., Hong X., Davrazou, F., Kutateladze, TG., Simpson, M., Mao, Q., Pan, CH., Dai, S., Hagman, J., Hansen, K., Shi, Y., and Zhang, G. (2006) . Structural insights into histone demethylation by JMJD2 family members. Cell Vol 125: 703-717.
3. Shi, YJ., Lan, F., Matson, C., Mulligan, P., Whetstine, JR., Cole, PA., Casero, RA. and Shi, Y. (2004). Histone demethylation mediated by the nuclear amine oxidase homolog LSD1. Cell Vol 119:941-953.
4. Sui, G.C., Affar, E.B., Shi, Y.J., Wall, N., Brignone, C., Yin, P., Dohonoe, M., Calvo, D. Grossman, S. and Shi, Y. (2004). Yin Yang 1 is a negative regulator of p53. Cell 117:859-872.
5. Lo, M-C., Gay, F., Odom, R., Shi, Y., and Lin, R.L. (2004). A 14-3-3 protein, PAR-5, mediates nuclear export of POP-1 in Wnt/MAP kinase responsive cells in C. elegans embryos. Cell Vol 117:95-106.
6. Shi, YJ., Sawada, J-I., Sui, G.C., Affar, E.B., Whetstine, J., Lan, F., Ogawa, H., Luke, M.,P-S., Nakatani, Y., and Shi, Y. (2003). Coordinated histone modifications mediated by a CtBP co-repressor complex. Nature Vol 422:735-8.
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